Detalhe da pesquisa
1.
Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB.
Cell
; 187(9): 2209-2223.e16, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670073
2.
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.
Nat Immunol
; 25(1): 178-188, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38012416
3.
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.
Cell
; 184(17): 4495-4511.e19, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34289345
4.
Massively parallel assessment of human variants with base editor screens.
Cell
; 184(4): 1064-1080.e20, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33606977
5.
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Cell
; 184(1): 76-91.e13, 2021 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147444
6.
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.
Nat Immunol
; 23(10): 1495-1506, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36151395
7.
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.
Cell
; 179(5): 1222-1238.e17, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31730859
8.
In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma.
Immunity
; 54(3): 571-585.e6, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33497609
9.
Targetable leukaemia dependency on noncanonical PI3Kγ signalling.
Nature
; 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38720074
10.
MEN1 mutations mediate clinical resistance to menin inhibition.
Nature
; 615(7954): 913-919, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922589
11.
MYC Controls the Epstein-Barr Virus Lytic Switch.
Mol Cell
; 78(4): 653-669.e8, 2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315601
12.
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.
Nat Methods
; 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38594452
13.
Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput.
Nat Methods
; 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38684783
14.
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Nature
; 595(7866): 309-314, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33953401
15.
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells.
Proc Natl Acad Sci U S A
; 121(1): e2315865120, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147552
16.
Transcriptional control of leukemogenesis by the chromatin reader SGF29.
Blood
; 143(8): 697-712, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38048593
17.
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
PLoS Biol
; 21(6): e3002097, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310920
18.
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression.
J Biol Chem
; 300(4): 107153, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38462163
19.
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Nat Immunol
; 14(2): 179-85, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23263557
20.
Base editor scanning charts the DNMT3A activity landscape.
Nat Chem Biol
; 19(2): 176-186, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36266353